ヒト口腔扁平上皮癌の移植・継代における維持安定性に関する研究
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Human squamous cell carcinoma, obtained in an operation on carcinoma of the floor of the mouth and carcinoma of the tongue, was transplanted to nude mice and also serially transplanted in nude mice. The carcinoma was examined by macroscopic observation, light microscopy and electron microscopy. Findings obtained on squamous cell carcinoma hyperplasia by macroscopic observation : In carcinoma of the floor of the mouth, the growth curves at the 5th, 20th, 40th and 60th passages were only slightly different. In carcinoma of the tongue, too, the growth curves were only slightly different. Findings obtained by light microscopy : In carcinoma of the floor of the mouth, the original carcinoma showed a mosaic arrangement, and heterotype of nuclei and cytoplasm were sometimes observed and keratinized areas were occasionally seen. In the course of the passages, connective tissue tended to decrease, whereas the vesicular contents preserved almost the same original state of carcinoma ever after passages. In carcinoma of the tongue, both the original carcinoma and the passage carcinoma were observed to have some fairly keratinized areas. Findings obtained by electron microscopy : In carcinoma of the floor of the mouth, the margin of each nucleus was uneven and irregular, the nuclei were bright and rich in euchromatin and polysomes were abundant in the cytoplasm. The intercellular space was wider than that of normal epithelial cells, and the number of desmosomes decreased in comparison with those of normal epithelial cells. However, little difference was recognized between the passage generations. In the electron microscopic images of carcinoma of the tongue after several passages, in addition to the above-mentioned findings of carcinoma of the floor of the mouth, concentric circles, in which one cell was surrounded by another's tonofibril, were observed. However, little morphological difference was detected between the passage generations.
- 福岡歯科大学学会の論文
- 1991-10-30
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