歯周疾患とβ-Glucuronidaseとの関係についての研究 : I. 血清,全唾液および濾過唾液中のβ-Glucuronidase活性値
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The β-Glucuronidase (β-G) activities in serum, whole saliva and filtrated saliva collected from patients with periodontal diseases were measured by a modified Fishman's method (Kaizu's method), and compared with various clinical findings such as PMA-index by Schour-Massler, OH-index (debris score+calculus score) by Green-Vermillion, depth of periodontal pocket (mm) and degree of bone loss by X-ray photos. The following results were obtained : 1. Significant differences of β-G activities were observed in whole saliva between the clinically healthy controls and patients with periodontal disease (P<0.01), although the serum β-G activities of both groups were within normal limits. 2. The β-G activities in whole saliva of the periodontal patients were observed marked correlations with PMA-index (P<0.05), pocket depth (P<0.01) and bone loss (P<0.001), but no significant correlation was found with oral hygiene index (P>0.05). 3. The value of β-G activities extracted from filtrated saliva were observed high correlation with the depth of periodontal pocket (P<0.05) and bone loss (P<0.001), but no significant correlations were observed with PMA-index and oral hygiene index (P>0.05). 4. The β-G activities of filtrated saliva were from 4 to 87 per cent lower than those of whole saliva, even though both unfiltrated and filtrated saliva samples were observed significant correlations with each other (P<0.001). 5. The β-G activities of periodontal disease groups were 3.3 times higher in whole saliva and 7.5 times were higher in filtrated saliva than those of normal group. 6. In the group of patients that were examined on the basis of clinical findings and X-ray photos, the β-G activities of both whole and filtrated saliva had a tendency to increase according to the progression of diseases. It is concluded from these results that the β-G activities in whole and filtrated saliva are closely related to the each clinical finding and process of periodontal disease.
- 特定非営利活動法人日本歯周病学会の論文
- 1975-03-28
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