IL-13 UPREGULATES TENASCIN SYNTHESIS IN DERMAL FIBROBLASTS
スポンサーリンク
概要
- 論文の詳細を見る
Tenascin-C (TN-C) is an extracellular matrix glycoprotein, transiently expressed during embryonic development. In adult tissues, the expression of TN-C is usually at lower level, but transiently induced in healing wounds and in the stroma of some tumors. And fetal calf serum and cytokines are known to induce TN-C expression in cultured cells. To clarify the mechanisms regulating TN-C expression, we investigated the effects of various cytokines (IL-13, IL-4, PDGF, TGF-β, Oncostatin M) on TN-C expression by dermal fibroblasts. IL-13 induced TN-C protein expression most strongly. And IL-13 increased TN expression in a dose- and time-dependent manner. Furthermore, IL-13-induced TN-C expression was inhibited by a protein kinase C (PKC) inhibitor calphostin C or a PI 3-kinase inhibitor wortmannin or LY 294002. These data suggest that IL-13 is one of the most potent inducers of TN-C. Moreover, PKC and PI 3-kinase may be key signal transducer responsible for the induction of TN-C expression in dermal fibroblasts by IL-13.
- 日本結合組織学会の論文
著者
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Yamane Kenichi
Department Of Dermatology Faculty Of Medicine University Of Tokyo
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TAMAKI Kunihiko
Department of Dermatology, Faculty of Medicine, University of Tokyo
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IHN Hironobu
Department of Dermatology, Faculty of Medicine, University of Tokyo
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Tamaki Kunihiko
Department Of Dermatology Faculty Of Medicine University Of Tokyo
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JINNIN Masatoshi
Department of Dermatology & Plastic and Reconstructive Surgery, Graduate School of Medical and Pharm
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Ihn Hironobu
Department Of Dermatology Graduate School Of Medical And Pharmaceutical Sciences Kumamoto University
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Ihn Hironobu
Department Of Dermatology & Plastic And Reconstructive Surgery Graduate School Of Medical And Ph
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Ihn Hironobu
Department Of Dermatology Faculty Of Medicine University Of Tokyo
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Ihn Hironobu
Department Of Dermatology And Plastic Surgery Faculty Of Life Sciences Kumamoto University
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Jinnin Masatoshi
Department Of Dermatology & Plastic And Reconstructive Surgery Graduate School Of Medical And Ph
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Tamaki Kunihiko
Department Of Dermatology Angiogenesis And Connective Tissue Metabolism Kanazawa University Graduate School Of Medicine
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