SYNTHETIC GLYCOPOLYMERS AS AN ARTIFICIAL ADHESION MATRIX

概要

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Cell adhesion to extracellular matrixes (ECMs) plays a pivotal role in cell survival, cell proliferation, and functions in animal tissue. Cell adhesions to biomaterials have been a concern in tissue engineering research. Cell adhesion to materials is initialized by cell surface molecules, while cooperating with material surface molecules through biological recognition or non-specific interaction. Recent medical applications have needed more highly functional biomaterials that have cell recognition. Sugar-carrying polystyrene was well-defined system for hepatocyte culture, since the polymer was stably adsorbed to polystyrene surface through hydrophobic interaction. In this study, we have tried to interpret the behavior of hepatocyte adhered to sugar-carrying polystyrene surface recognized by asialoglycoprotein receptor (ASGP-R). Integrin-mediated signaling pathway in primary hepatocyte could be quantitatively regulated by geometric structure of the synthetic glycopolymers surfaces. We believe that these findings could be helpful for study of integrin-dependent cell signaling in normal cell type and for design of high functional matrix in tissue engineering.
日本結合組織学会の論文