Glycosaminoglycans and Glycoproteins of Animal Bladder(Special Issue on "Hyaluronan")

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概要

• 論文の詳細を見る

• There is considerable evidence that the bladder glycoconjugates are involved in the pathophysiology of various bladder disorders such as microbial infections, bladder carcinoma and interstitial crstitis. Based on circumstantial evidence, glycosaminoglycans were originally suggested to be the major glycoconjugate component of the urothelium. However, the results of recent biochemical studies in our laboratory are in agreement with those of the majority of investigators that the urothelium contains a high concentration of glycoproteins but only trace amounts of glycosaminoglycans. Histochemical staining, using antibodies and lectins, confirm the paucity of GAGs and an abundance of glycoproteins on the luminal surface of bladders. Several glycoproteins of the mucosal epithelium, including two high molecular weight mucins, have been recently purified and characterized. In contrast to the mucosa, the underlying lamina propria and muscle layers of bladders are rich in hyaluronan and chondroitin 4-sulfate. In this review, some of the investigations which contribute to the current knowledge of glycosaminoglycans and glycoproteins associated with animal bladder are summarized.

• 日本結合組織学会の論文
• 2001-09-25

著者

• Bhavanandan Veer

  Department Of Biochemistry And Molecular Biology The Pennsylvania State University College Of Medici

関連論文

• Glycosaminoglycans and Glycoproteins of Animal Bladder(Special Issue on "Hyaluronan")

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