Hyaluronan Biosynthesis:A Multifaceted Process(Special Issue on "Hyaluronan")

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概要

• 論文の詳細を見る

• Hyaluronan is a major polysaccharide found in extracellular matrices and is involved in a wide variety of biological events including morphogenesis, tissue generation, inflammation and tumor progression. This polysaccharide interacts with cell surface receptors and affects cell adhesion, migration, growth and differentiation. These physiological roles of hyaluronan vary considerably depending on its physical nature, which is primarily determined during its biosynthesis. A lot of work has been done to elucidate hyaluronan biosynthesis, but there still some important, unsolved issues : how hyaluronan biosynthesis is regulated and what the mechanism is for determining hyaluronan size? The key mammalian enzymes in hyaluronan biosynthesis are the hyaluronan syntheses : three of which have been successfully cloned and identified. Expressing any one of these hyaluronan synthases in mammalian cells leads to de novo hyaluronan biosynthesis, indicating that each HAS protein is independently able to catalyze hyaluronan biosynthesis ; however, we recently obserbed that the HAS isoforms are not equivalent in their intrinsic enzymatic properties, providing some insights into the enzymatic basis for differences between hyaluronan physical properties and explaining how different sizes of hyaluronan are different in their physiological roles. This review discusses the different HAS isoforms and their enzymatic properties in order to highlight the diverse and multiple regulatory mechanisms for controlling hyaluronan biosynthesis.

• 日本結合組織学会の論文
• 2001-09-25

著者

• Itano Naoki

  Institute For Molecular Science Of Medicine Aichi Medical University

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• Hyaluronan Biosynthesis:A Multifaceted Process(Special Issue on "Hyaluronan")

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