The Role of Mesenchymal Tissue in the Development of the Gut

概要

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The developing gut in vertebrates provides a good system for the analysis of tissue interactions working in the formation of many organs, because it is composed of epithelial tissue and mesenchymal tissue both of which have their own differentiation markers. Our recent study revealed that gradual determination of regionality in the epithelium involves complex gene cascades regulated always by the influence of the mesenchyme. Thus the first sign of differentiation is related to expression of cSox2 in the anterior part of the gut and of CdxA in the posterior part. Next, in the anterior part, stomach region is established by some influence from the mesenchyme, which involves the effect of bone morphogenetic protein-2. Moreover, the stomach epithelium becomes subdivided into glandular and non-glandular ones, and glandular epithelial cells are capable of expressing specific genes under the influence of some transcription factors, expression of which is again under the control of the mesenchymal tissue.
日本結合組織学会の論文
2000-09-25