Role of Proteoglycans in Retinal Development and Retinal Injury

概要

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Recent developments in molecular biological techniques have revealed that many proteoglycans are highly expressed in developing retina. Accordingly, we investigated the expression of decorin, a small chondroitin / dermatan sulfate proteoglycan, and neurocan, a neural tissue-specific chondroitin sulfate proteoglycan(CSPG), in rat retina. In adult rat retinas, decorin is distributed throughout the retinal inner layers, such as the nerve fiber layer(NFL), ganglion cell layer(GCL)and inner plexiform layer(IPL). In developing retinas, strong immunoreactivities for decorin shift to the GCL as development proceeds. In contrast, neurocan is distributed in the axon-rich layers, such as the IPL and the outer plexiform layer(OPL), in early postnatal rat retina, but not in adult rat retina. Moreover, the immunoreactivities of these proteoglycans increase after transient retinal ischemia in rat retinal ischemia-reperfusion models. These investigations on the expression and biologic activities of proteoglycans in both physiologic and diseased retinas may shed new light on the pathogenesis and potential treatment of various retinal diseases.
2000-03-25