Transcriptional Activation of Type I Collagen Gene during Hepatic Fibrogenesis

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概要

• 論文の詳細を見る

• Increased production of type I collagen is a common hallmark of fibrotic diseases in various organs including the liver. This increase is exerted mainly by transcriptional upregulation of the genes coding for the α1 and α2 chains of type I collagen. We have shown that the-378 to+58 upstream sequence of a2(I)collagen gene(COL1A2)is essential for basal transcription in skin fibroblasts and hepatic stellate cells. In addition, the-313 to-183 region is responsible for stimulation of the gene expression by TGF-β. We therefore designated this region the TGF-β-responsive element, and revealed that a ubiquitous trans-activator Spl and unknown nuclear factor(s)bind to this region to mediate the stimulatory effect of TGF-β. Experiments using transgenic mice harboring the COL1A2 upstream sequence linked to a β-galactosidase gene have revealed that the same -313 COL1A2 promoter is activated in a cell type-specific manner during hepatic fibrogenesis in vivo.

• 日本結合組織学会の論文
• 1999-09-25

著者

• Ramirez Francesco

  Brookdale Center for Molecular Biology, Mt. Sinai School of Medicine, Guatave Levy Place

• Inagaki Yutaka

  Department Of Internal Medicine And The Division Of Clinical Research National Kanazawa Hospital

• Inagaki Yutaka

  Department Of Community Health Division Of Community And Environmental Health Tokai University Schoo

• Inagaki Yutaka

  Department Of Internal Medicine And Clinical Research Institute National Kanazawa Hospital

• Nemoto Tomoyuki

  First Department Of Internal Medicine Kanazawa University School Of Medicine

• Ramirez Francesco

  Brookdale Center For Developmental And Molecular Biology Mount Sinai School Of Medicine

• GREENWEL Patricia

  Brookdale Center for Developmental and Molecular Biology, Mount Sinai School of Medicine

• Greenwel Patricia

  Brookdale Center For Developmental And Molecular Biology Mount Sinai School Of Medicine

関連論文

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• Transcriptional Activation of Type I Collagen Gene during Hepatic Fibrogenesis
• Treatment Strategies for Organ Fibrosis Based on Regulation of Collagen Metabolism
• Transcriptional Regulation of Type I Collagen Gene Expression by Transforming Growth Factor-β/Smad Signaling and Its Antagonistic Factors
• ROLES OF SMAD PROTEINS IN TRANSCRIPTIONAL REGULATION OF COLLAGEN GENE EXPRESSION IN ACTIVATED HEPATIC STELLATE CELLS
• Elastic Collagenous Networks in Vascular Diseases
• Transcriptional Regulation of Type I Collagen Gene Expression by Transforming Growth Factor-B and Smad Signaling
• MOLECULAR BASIS FOR ANTI-FIBROTIC EFFECTS OF INTERFERON ALPHA
• Interplay between bone marrow and liver in the pathogenesis of hepatic fibrosis

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