血小板とコラーゲンの相互作用

概要

論文の詳細を見る
Adhesion of platelets to the damaged subendothelium is a prerequisite reaction for the initiation of hemostasis in vivo. Collagen is a major component of the subendothelium and the interaction of platelets with collagen would be the initial reaction of thrombus formation in blood vessels. At present, two platelet membrane glycoproteins, integrin α_2β_1(GP Ia / IIa)and GP VI, are recognized as physiological collagen receptors. Integrin α_2β_1 shows a high affinity to collagen after platelet activation and GP VI induces platelet activation by signaling pathway of tyrosine phosphorylation. In the physiological conditions, especially in the flowing conditions, both of these two collagen receptors are required for inducing thrombus formation.
日本結合組織学会の論文
1999-03-25