Hepatic Stellate Cells

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概要

• 論文の詳細を見る

• The hepatic stellate cells were first described by Kupffer in 1876, using the gold chloride method. At that time these cells were thought to be perisinusoidal connective tissue cells. However, a misconception by himself in 1898 led to a deep-rooted confusions in liver histology. I rediscovered the original stellate cells by the use of Kupffer's gold method in 1971. These cells are now known as the vitamin A-storing cells which locate perisinusoidally and produce collagens and other extracellular substances. Three-dimensional entire forms of the stellate cells are effectively demonstrated by the Golgi's silver method. Their dendritic processes wrap the endothelium of sinusoids. Numerous spine-like microprojections of the stellate cells make spotty contacts with hepatocytes. The space of Disse is the space between the endothelial cell-stellate cell complex and the hepatocytes, being bridged by the spines. Intralobular heterogeneity of these cells is examined in relation to the microcirculation and the fibrogenesis.

• 日本結合組織学会の論文
• 1998-09-25

著者

• WAKE Kenjiro

  Department of Anatomy II, School of Dental Medicine, Tsurumi University

• Wake K

  Tokyo Medical And Dental Univ. Tokyo Jpn

関連論文

• Characterization of vitamin A-storing cells in mouse fibrous kidneys using Cygb/STAP as a marker of activated stellate cells
• Nervous Organization of the Pineal Complex in Lower Vertebrates
• Cell-cell organization and functions of 'sinusoids' in liver microcirculation system
• Mesangial Cells of the Lamprey, Lampetra japonica, Store Vitamin A
• Hepatic Stellate Cells

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