The Pathogenesis of Liver Fibrosis : A Role for Altered Matrix Degradation

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概要

• 論文の詳細を見る

• Hepatic stellate cells(HSC)are involved in regulating matrix degradation in liver. In early liver injury or in early HSC culture there is increased expression of metalloproteinases that are capable of degrading normal liver matrix including gelatinase A, stromelysin-1 and MT1-MMP. There is increasing evidence to suggest that action of gelatinase A is profibrogenic, possibly mediated via disruption of cell matrix interactions or release of matrix bound growth factors. In advanced liver disease and in the later phases of HSC culture there is net inhibition of degradation of fibrillar liver matrix. This is mediated by increased expression of TIMP-1 and TIMP-2 relative to interstitial collagenase by fully activated HSC. Recent evidence indicates that decreased expression of TIMPs relative to interstitial collagenase is the mechanism by which fibrillar matrix is degraded as liver fibrosis resolves after cessation of liver injury. These studies indicate that alterations in matrix degradation play a significant role in the development, progression and resolution of liver fibrosis.

• 日本結合組織学会の論文
• 1998-09-25

著者

• Mann D.a.

  University Of Southampton Uk

• ARTHUR M.J.P.

  University of Southampton, UK

• BENYON R.C.

  University of Southampton, UK

• IREDALE J.P.

  University of Southampton, UK

• Benyon R.c.

  University Of Southampton Uk

• Iredale J.p.

  University Of Southampton Uk

• Arthur M.j.p.

  University Of Southampton Uk

関連論文

• The Pathogenesis of Liver Fibrosis : A Role for Altered Matrix Degradation

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