Signal Transduction of Proteoglycan-type Protein Tyrosine Phosphatase, PTPζ(<Special Issue>Roles of Extracellular Matrix in the Development and Regeneration of Nervous Systems)
スポンサーリンク
概要
- 論文の詳細を見る
PTPζ (RPTPβ) is a receptor-type protein tyrosine phosphatase, which is synthesized as a chondroitin sulfate proteoglycan. The extracellular region of this receptor is secreted as a soluble brain-specific chondroitin sulfate proteoglycan, phosphacan. These transmembrane and secreted forms are generated by alternative splicing. The extracellular region of PTPζ binds various molecules such as pleiotrophin, midkine, FGF-2, contactin, N-CAM, TAG-1, and sodium channel, and is thought to play important roles in the regulation of cell adhesion, migration and neuronal excitability.
- 2003-03-25
著者
-
Maeda N
Department Of Developmental Neuroscience Tokyo Metropolitan Institute For Neuroscience
-
Maeda Nobuaki
Department Of Molecular Neurobiology National Institute For Basic Biology
-
Maeda Nobuaki
Department Of Developmental Neuroscience Tokyo Metropolitan Institute For Neuroscience
関連論文
- Signal Transduction of Proteoglycan-type Protein Tyrosine Phosphatase, PTPζ(Roles of Extracellular Matrix in the Development and Regeneration of Nervous Systems)
- Two types of brain chondroitin sulfate proteoglycan: their distribution and possible functions in the rat embryo