慢性辺縁性歯周炎患者の血清β-リポ蛋白値の変動について
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概要
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β-Lipoprotein, which is located at β-globulin in terms of electrophoresis, has been known for many years. Centrifugally, this substance belongs to low-density β-Liporotein and its own density is established at twofold measurement of 1.019~1.063 and 1.006~1.019. However, the particle size falls the midway between ,α-Lipoprotein and pre-β-Lipoproten. Being a complex protein made up of fatty substance and protein as its main components, β-Lipoprotein is generally held to play an important part both in the transfer and metabolism of fatty substance.A full-scale research on β-Lipoprotein can be said to have begun just recently because of difficulties involved in its storage, unstability of its molecules and analytical methods. Yet, by way of clinical implications, the anomaly of β-Lipoprotein has been reported in the blood serum of patients suffering from the cases of arterioscleosis, liver complaints, and other diseases, and the level of β-Lipoprotein is given much importance in determining a diagnosis. In the oral realm, on the other hand, research efforts on β-Lipoprotein are still rather scanty except those by Miyamoto and others, who reported that, as compared with controls, the level of β-Lipopro-tein in an experimental group of the periodontal patients was somewhat higher. In the present study, the author conducted the measurement of values of β-Lipoprotein in the blood serum in association with the progree of chronic cases of marginal periodontitis. At the same time, further effort was made to look into changes, that occurred both before and after the treatment of these cases, so that some interesting correlations might be found. By way of study material, a total of 330 subjects was carefully selected. The subjects thus selected consisted of 124 male and 122 female patients diagnosed as the casese of chronic marginal periodontitis in the Department of Periodontology, Nihon University School of Dentistry from January 1971 to October 1973, and 42 healthy males and 42 healthy females of the same age, the latter serving as controls. As and experimental method employed, the value of β-Lipoprotein of a given periodontal patient was measured on his or her initial examination and, subsequently, a treatment was undertaken. An operative or conservative treatment was effected to the group P_l patients, whereas surgical treatments were effected to the groups of P_2 and P_3 patients for the upper and lower jaws. At time-points where the wound surfaces of first operations appeared to be nearly healed, that is, in 20 to 40 days post-operatively, the blood was collected for the second time. With these blood samples, the values of β-Lipoprotein were measured with the Heparin-Ca sedimentation method. On the strength of the findings, the author arrived at the following conclusions. 1. As for the values of β-Lipoprotein, there was no statistical signinficance between the male and the female. 2. The values of β-Lipoprotein revealed a tendency of increase proportionally to the age both in the normal subjects and patients of chronic marginal periodontitis. 3. When examined in different degrees of the disease (P_l→P_2→P_3), the level of β-Lipoprotein was observed to increase in proportion to the aggravation of the disease. Compared postoperatively, all these three groups showed a tendency of decrease than preoperatively. 4. From the findings given above, it is to be concluded that the chronic marginal periodontitis has some kind of correlation to the level of β-Lipoprotein in the blood serum.
- 特定非営利活動法人日本歯周病学会の論文
- 1975-09-25