ウサギ,ラットの除神経筋に対するepinephrineの作用

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l. The effects of epinephrine and trinnetoquinol on chronically denervatedskeletal muscles were studied in and compared between rabbits and rats.2L In rabbits, epinephrine (5 to 10 7zg/kg intravenously) produced a decrease in restingtension and in the frequency of spontaneous discharges. T he change in tension wasdiminished by both propranolol and phentolamine, vxhile the change in electrical activitieswas abolished mainly by phentolamine.3. In rats, on the other hand, epinephrine (5 to 50 pg/kg iuttravenously) caused an in-crease in tension and the frequency of discharges. Its enhancing effects were diminished byphentolamine.4. Trimetoquinol caused a slight decrease in tension on dertervated muscles of rabbitsand rats. This effect was antagonized by propranolol alone. Little or no changes in elec-trical activities were observed by administration with this drug.5. The responses of the extensor digitorum longus and soleus muscles to the drugs werequalitatively the same in both species.
社団法人日本獣医学会の論文
1974-02-25