Biological Cryo-Atomic Force Microscopy: Instrumentation and Applications

概要

論文の詳細を見る
Although atomic force microscopy (AFM) has been successfully applied to a number of biological specimens under aqueous solution, its resolving power has been limited due to specimen deformation or damage induced by the scanning tip, especially with large flexible and heterogeneous specimens. To further expand the capabilities of the AFM, a cryo-AFM was recently developed to operate under ambient pressure in liquid nitrogen vapor. The operating principle of this novel system is discussed, and some of the most recent applications of the cryo-AFM to various biological specimens are reviewed. These results have clearly demonstrated the power of the cryo-AFM in the study of biological structures, and at the same time, have revealed novel structural information of several important molecules.
社団法人応用物理学会の論文
1998-06-30