The Envelopment of Malignant Tumor Cells using the Fuzzy Set Chaos Theory during Histological Regulation

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概要

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• We have established how to regulate tissue histology by using the Fuzzy Set Chaos Theory(BMFSA Sep.Sympo., pp^<1-2> 1995). We applied this theory to metastatic tumor cells that proliferate rapidly and migrate into adjacent tissue and organs. The basic flow chart of the histological regulation was to search effective molecules in database and to plane gene expression by programming to envelop a metastatic malignant cell by commanding fibroblast to move around the metastatic cells in the tissue. The ON commands we used were 1)synthesize collagens by ascorbic acid(VC), 2)increase collagen mRNA traslation by supplying collagen and calcium enriched small dried fishes after steam heating, 3)enveloped metastatic cells by combining collagen with elastin activated by calcium, 4)proliferate fibrogenic cells by thiamin(VB_1), riboflavin(VB_2), pyridoxine(VB_6), cobalamin(VB_<12>). A cut off supply of each molecule was used for the OFF command. Commands were transmitted by blood current, effluxed from blood vessels, parts of which with increased permeability induced by bradykinin, cytokines, and chemokines around the metastatic cells. These cytokines and chemokines transmit to fibroblasts the location of the metastatic cells. The effectiveness was monitored by X-ray photography or CT-scan and was judged by patients' viability.

• バイオメディカル・ファジィ・システム学会の論文

著者

• Hirano H

  Biochemistry University Of Occupational And Environmental Health

• Hirano Hideyasu

  Biochemistry School Of Medicine University Of Occupational And Environmental Health Japan

• Arai Akihiro

  Pediatrics University Of Occupational And Environmental Health

• Hirano Takeshi

  Env.oncology:university Of Occupational And Environmental Health

• Tamura Masahito

  Intl.med. University Of Occupational And Environmental Health

• Harada Kazunori

  Surg.:amakusa Med.center

• Nakano Masahiro

  Health Infor.Science, University of Occupational and Environmental Health

• Arashidani Keiichi

  Env.Manage., University of Occupational and Environmental Health

• Nakano Masahiro

  Health Infor.science University Of Occupational And Environmental Health

• Arashidani Keiichi

  Env.manage. University Of Occupational And Environmental Health

関連論文

• cDNA Cloning of Inducer Reactive Protein in Adult T-Cell Leukemia Cells by Applying the Fuzzy Set Cloning Theory for Sequencing Defuzzification
• The Envelopment of Malignant Tumor Cells using the Fuzzy Set Chaos Theory during Histological Regulation
• A Novel Approach for Obtaining acDNA Clone that Codes Functional Protein by Applying the Fuzzy Set Cloning Theory

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