疲労の消長とビタミンの作用
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概要
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To see the relationship between the living body in a dynamic state by load and instantaneous effects of vitamins, two series of experiment were made. On the somatic fatigue, the effects of the difference of the administration time was examined. On the mental fatigue, the mechanism of the effects of instantaneous preventive administration was investigated. A. Experiments on somatic fatigues. Groups of rats (Group I,II, and III) were fatigued by enforced swimming till they were cap-able no more swimming. The swimming was loaded 3 times, with 30 minutes rest between the 1st and the 2nd, and 60 minutes rest between the 2nd and the3rd. Every data was compared by the percentage of the duration of the 1st swimming. Group I was the control without injection. Group II was injected just before the 2nd and the 3rd swimming. Group III was injected just after the 1st and the2nd swimming. The experiments (A,B,C, and D) were repeated with several days interval. In the experiment A, thiamine 2.5 mg, in the experiment B, glucose 50 mg, in the experiment C, thiamine 2.5 mg+glucose 50 mg, and in the experiment D, thiamine 2.5mg or glucose 50 mg etc. were injected subcutaneously. The results obtained were as follows: (1) Thiamine is effective when it is administered at the beginning of recovery. But even with such administration glucose has no effects if it is administered just before the next swimming. (2) Thiamine+glucouse is effective to prolong the endurance time when it is administered before swimming. (3) It seems that the thiamine which is used effectively during recovery is either excreated or altered if it has been administered before glucose administration. B. Experiments on mental fatigues. It was investigated on human subjects whether or not variations of flicker fusion values, patella reflex thresholds, successive reaction time, and EEG by loaded Kraeperin Test were altered by injections in advance of thiamine, riboflavine, and ascorbic acid. The results obtained were as follows: (1) Thiamine (less than 10-15 mg) acts to bring back the cerebral excitation level to the normal steady state. Such effect is recognized as soon as 15 minutes after the injection and maintained 30 minutes or longer. But thiamine in amount more than 30 mg elevate the cerebral excitation level. (2) Riboflavine also shows the same attitude by the difference of doses, but it seems rather more excitable. (3) Ascorbic acid has no such effects in any dose.
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