INHGによる結核予防内服の効果について
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In recent years, isonicotinyl hydrazide (INH) has been used widely as a chemotherapeutic against tuberculosis. At the same time, numerous studies have been carried out to prepare its derivatives in order to decrease its toxicity and increase its therapeutic effect. One of these is sodium glucuronate of isonicotiny lhydrazone (INHG), which was found to bel ess toxic and fairly effective, both experimentally and clinically, by G. Brouet, Kitamoto, Oohira and Akamine. Persons with suspicion of tuberculosis were placed under medical supervision. Eight such persons were chosen for the present test and 0.6 g of INHG (6 tablets of "Hydronsan") per day was given every day since June, 1958. Variations in physique and physical strength, and effect on prevention of recurrence were examined. Following results were obtained, although number of treated cases was rather small. 1. Body weight tended to increase and blood cell sedimentation rate was found to decrease by administration, even when the value had been normal. 2. One of the persons under observation was first positive to bacillary tests in sputum. During oral administration of INHG, however, this case became negative and none was found to become positive. 3. No side effects, such as gastrointestinal disturbances, fatigue, anorexia, dizziness, or increase of coughing and sputum discharge, were observed by oral administration of INHG. 4. From X-ray observation of the lung field, betterment was observed in all cases except two with sclerotic image which remained unchanged. There was no case of recurrence.
- 社団法人日本産業衛生学会の論文
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