新抗生物質農薬ブラストサイジンSの毒性に関する研究 : 第1編ブラストサイジンSの急性毒性について

概要

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Blasticidin S is a new antifungal substance isolated from the culture broth of streptomyces griseochromogenes Fukunaga by Takeuchi, S., Hirayama, K., et al. in 1957. This antibiotic is remarkably effective against the rice blast both in its control and treatment. It was approved by the government in 1961, and has been put to practical use since then in Japan. The toxicity of BcS for mammals, however, is rather strong. The chemical has the property to attack selectively mucosa, particularly that of intestine and conjunctive and cornea of the eye. As a result, some of the workers in manufacturing plants of BcS and the farmers spraying it have come to complain of the eye irritation or disturbances of the degestive organs. For the purpose of reducing such occupational hazards the author made experiments on the acute toxicity of several BcS derivatives and eye and dermal irritations for laboratory animals. The result was that the acute toxicity was strongest in BcS-free base, moderate in BcS-C (laurylsulfonate salt), and lowest in BcS-3 (benzylamino benzene su fonate salt). As the symptoms of BcS poisoning, nasal hemorrhage and diarrhea were noticed. At necropsy, exsudate was found in the abdomen in most cases of the mice, suggesting the peritonitis; and as histo-pathlogical findings, spleen showed acute inflammation, liver appeared rather degenerative, and in kidneys congestion was marked.
社団法人日本産業衛生学会の論文
1966-02-20