じん肺症の肺機能障害に関する研究
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概要
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According to the regulation of the Pneumoconiosis Act (1960), roentgenological classification of the type of pneumoconiosis, Maximum Breathing Capacity, and Exercise Index were studied in 824 workers exposed to dust and 222 healthy adults. There were not so significant correlations between X-ray findings and pulmonary function disterbances. Most of PR_1 and PR_2 showed normal or slight disorder in functional tests. As to % MBC, PR_1 and PR_2 showed normal while PR_3 was mostly under 90%. As to Exercise Index, PR_2 was above 25%. Comparison of alveolar gas exchange during the step-up exercise tests were made among three groups (69 cases in total), i.e. silicosis (48 cases), tuberculosis (11 cases) and healthy adults (11 men). In these cases, exercise ventilation (ventilation during the third minute of exercise), oxygen uptake, oxygen removal, presence of oxygen debt at the fifth minute after exercise, rate of arterial blood oxygen saturation, carbondioxide tension of arterial blood, and intrapulmonary distribution of inspired gas were measured. 48 cases of silicosis were classified in four groups and the progress of the disease was discussed. First Group … Emphysematous changes advanced, alveolar hypoventilation and uneveness of intrapulmonary distribution of gas appeared. Exercise Index showed normal value while % MBC decreased. This group was often under estimated in the screening test practice as prescribed by the Pneumoconiosis Act. Second Group … Fibrotic changes advanced, disturbance of oxygen uptake was greater than ventilatory disturbance. Rate of oxygen saturation in arterial blood decreased. In this group, % MBC decreased and Exercise Index increased. Third Group … Insufficiency of gas exchanges were compensated by hyperventilaton. This group was divided in two subgroups, adequately compensated (sub-A) and inadequately compensated (sub-B). Both sub-groups showed normal level of oxygen saturation during exercise but oxygen debt exsisted in sub-A and not in sub-B. In sub-B group, Exercise Index showed relatively high value while % MBC was normal. This group was often overestimated in the practice of the screening tests. Fourth Group … Normal gas exchange level was maintained.
- 公益社団法人日本産業衛生学会の論文
- 1964-01-20