亜硫酸ガス中毒に関する臨床的ならびに実験的研究 : 第III編 慢性亜硫酸ガス中毒家兎に重曹を注射したさいの血清中Cl, Na, K, Caについて
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After 2-hour exposure to sulfur dioxide of 100 ppm, 7 male rabbits of body weight of 2,500 to 3,000 grams were injected through an auricular vein each with 7cc of a 7% sodium bicarbonate solution caily, and a 6-month tracing of the variations in the amounts of serum chlorine, sodium, potassium and calcium was made. The following results were obtained. 1) As mentioned in Part II, marked alterations were recognized in the amounts of serum sodium and potassium whereas none were in the amounts of chlorine and calcium. Sodium amount exhibited a decrease on the 7th day of the experiment down to 78.9% of the value prior to experiment, but thereafter an increase with a peak on the 35th day up to 130.2% of the preexperiment value was noted. From that time on comparatively high values were shown until the 49th day, but there was a subsequent decline in the values in the remaining experimental period, values becoming in some measure lower than those prior to experiment. Potassium amount decreased to 77.4% of the preexperiment value on the 7th day of the experiment, and this condition continued almost throughout the subsequent period. So far, the results are similar to those stated in Part II. 2) In the present case, however, with a view to knowing the effects of sodium bicarbonate, next, 4 rabbits were injected with 7cc of a 7% sodium bicarbonate solution alone without the inhalation of sulfur dioxide. In this group noparticular change wa srecognized in the amounts of chlorine, sodium, potassium and calcium in the serum. 3) Then in another group of rabbits receiving the injection of sodium bicarbonate after the inhalation of sulfur dioxide, the increase in sodium got delayed and the peak of the increase made its appearance about two weeks later, and even the period showing a comparatively high value was a little longer than that in the formor group. However, sodium amount in the present group was less than that in the former by 10% or so in the late stage. 4) On the basis of the above findings, it was considered that injection of sodium bicarbonate in the case of chronic sulfur dioxide poisoning would delay the appearance of resistance and hasten the time of losing the resistance acquired. Accordingly, the administration of sodium bicarbonate is thought to be rather injurious without production any effectiveness in chronic sulfur dioxide poisoning.
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