Dimercaptosuccinic Acid (Meso型)の重金属排泄効果に関する実験的研究 : とくに鉛,水銀について

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So far possibility of preventive medical application of dimercaptosuccinic acid (D.M.S.) has been studied so little that we have almost a virgin land, where detoxication of heavy metals, prevention of radiation injuries, and other pharmaceutical and pharmacological investigations have to be cultivated. Having surveyed results concerning D.M.S. hitherto reported, the present author considered that it would be significant to apply the acid to the detoxication of lead and mercurial poisonings, and performed a series of experiments to see its effectiveness. Experiments in acute poisoning, LD 50 and its observation, were made on mice. Changes in the body weight, blood findings, urinary findings, and the quantity of lead and mercury excreted into the urine of lead- and mercury-admin istered rabbits, were seen under administration of D.M.S. And the effectiveness of D.M.S. was judged by comparing its results with those obtained by the use of BAL and Ca-EDTA, and with the results of the control group. The results are as follows. 1. LD_<50> of D.M.S. on mice was found to be 3,132mg/kg (±44mg/kg) by probit method. 2. Mice were subjected to acute poisoning and put under observation. Abnormality was not found up to the dosis 2.8g/kg, a slight though temporary change was seen at 2.9g/kg, and at 3.0g/kg it became remarkable. Just before their death came dyspnea and deep breathing in turns, tail-raising, pupillary dilation, and short fits of convulsions. Those convulsions were of tetanic-clonic type, and their recurrence was fatally serious with short intervals every time. Other symptoms immediately before death were generally inhibitory-pilo-erection, swaying of the body, cyanosis, lying on the side, and repeated fits of tetanic-clonic convulsions occurring at special locations of the lower parts of the leg and at muscles of mastication. 3. Decreasing in body weight of rabbits was the smallest in the D.M.S.-administered group, especially in the lead poisoning. 4. Blood findings. In the D.M.S.-administered group an early recovery of anemia was seen and erythrocytes with basophilic stipplings were likely to appear in far less degree and disappeared more quickly. 5. Urinary findings. In the D.M.S.-administered group diminution of the urine amount was prevented, and this effect was seen markedly in mercurial poisning. Disturbance of renal functions due to lead-poisoning was slightly less in degree in the BAL-administered group and in the Ca-EDTA-administered group. The renal disturbance due to mercurial poisoning was least in the D.M.S.-administered group. 6. The excretion-promoting effect of D.M.S. for heavy metals progressed day after day, the excreted concentration of the metals becoming higher and higher as days went on, and the excretion was completed comparatively early. But D.M.S. was somewhat different form Ca-EDTA and BAL which caused excretion in large quantity immediately after administration. The total quantity of the excreted lead during the experimental period was larger in the D.M.S.-administered group than in the Ca-EDTA-administered group but less in the BAL-administered group. That of mercury was the largest in the D.M.S.-administered group.
社団法人日本産業衛生学会の論文
1968-06-20

著者

白石陽治
日本大学医学部公衆衛生学教室

Dimercaptosuccinic Acid (Meso型)の重金属排泄効果に関する実験的研究 : とくに鉛,水銀について

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