珪肺症に関する研究 : 第3報純粋な滑石の気管内注入による家兎肺組織の変化

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Experimental talcosis, entirely different from silicotic chenges, warw presented by applying absolutely pure talc which had been determined to be free from α-quartz content by qualitative and quantitative an alysis with X-ray siffraction method (Norelco) and phosphoric acid method. 1) Talc, through 200 mesh, was pulverized into less than 5 μ_ο The powder was added to 6 cc Ringer's Solution at 1.0gand sterilized in autoclave. This Preparation (3cc) was injected into trachea of rabbits (containing talc 500 mg). 2) For comparison, another groups of rabbits ware given injection of α-quartz 500 mg respectively. 3) Subjects were histologically checked, grouping into three, after one month, three months and six months. 4)The talc injected subjects unexceptionally produced granulation in alveoli, but marked fibrosis and fusion of nodules were not observed. No swelling was noticed at thorax lymph glands, presenting only image of agglomerated talc particles. 5)With α-quartz injected subjects, fibrosis was extreme. Blood vessels were also affected. Lymph glands ware swollen as big as rice grains at the end of three months, and as beans after six months, demonstrating marked proliferation of connective tissues. 6) It is possible that clinical talcosis is caused by the silicotic chenges to add to that from talc since α-quartz is contained in industrial talc dust.
社団法人日本産業衛生学会の論文