実験的アニリン及びニトロベンゼン中毒家兎の視神経の病理組織学的研究

概要

論文の詳細を見る
0.2ml/kg of aniline or 0.05ml/kg of nitrobenzene was injected daily subcutaneously to male adult rabbits. Each group of the experimental animals was killed respectively at every week end until the 12th week and pathohistological changes of the optic nerve were investigated employing the such staining methods as Marchi granules by Kuru myelin sheath by Sugamo, axis cylinder by Bielschowsky, haematoxylin-eosin by P.Mayer, macroglia by Cajal, glial fider by Weigert, glial cell by Alzheimer-Mallory, and azan. Changes occurred in the second week, showing Marchi granules and regressive Changes of the glial cell in both groups administered with aniline and with nitrobenzen. Afterwards, gliosis took place in the sixth week aniline gyroup, accompanied with degeneration of glial cells. The degenerative chabge was somewhat stronger in the nitrobenzen than in the aniline group. These atrophic glial cellswere always found in the nitrobenzene administered rabbits, even in the later stadium of poisoning. Changes in the myelin sheath became stronger and stronger according to the long term administration and demyelinization was seen at last. Lesions in the axis cylinder were found at the third week end by in the nitrobenzene group and at the third week end by in the nitrobenzene group and at the forth week end in the aniline group. Findingsin the mesenchymal tissufe in the early stadium of poisoning were perivascular round cell infiltration and those in the later stadium were hyperplasy of the septal connective and the advential tissues.
社団法人日本産業衛生学会の論文

著者

吉田鉄也
神戸医科大学衛生学教室

実験的アニリン及びニトロベンゼン中毒家兎の視神経の病理組織学的研究

スポンサーリンク

概要

著者

関連論文

スポンサーリンク