有機フッ素剤(モノフルオロ酢酸アミド)の治療剤に関する研究
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概要
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Sodium monfluoroacetate has been introduced in Japan after the II War as an rodenticide against wild rats and some poisoning cases have been reported each year. Later monofluoroacetamide was put on the market as the insecticide for citrus orchards and its consumption is increasing every year. The present experiments were planned to find out effective antidotes against this economic poison. 1) LD_<50> of monofluoroacetamide for rats was 3.2 mg/kg by intraperitoneal route, leading animals to death in three or four days. LD_<90> was around 6.3 mg/kg. The intoxication dosis was fixed at 6mg/kg throughout these experiments and antidotes were given three times, at 1st, 4th and 7th hour following the administration of the poison. 2) The most effective antidote was acetamide or ethanol, both reducing the death rate down to two-third. Monoacetin, which is widely approved as the best remedy. was somewhat inferior to these. 3) Other drugs, which prolonged the surviving period, were procain amide, orotic acid (B_<13>), adrenochrome-semicarbazide, and sodium arsenate. 4) GABOB (γ-amino-β-hydroxy-butyric acid) and chloropromazine effectively inhibited the convulsion but no improvement of the surviving rate was observed. 5) The combined administration of acetamide, ethanol and procain amide showed the best result, reducing the death rate down to one third. The combination of monoacetin, ethanol and sodium arsenate was also excellent, reducing the rate down to one half. 6) The citric acid accumulation in tissues was also reduced when the drugs were effective on the surviving rate. This might be understood that these drugs had the good reason as antidotes from the standpoint of the biochemical mechanisms of poisoning proposed by R.A. Peters. 7) Fluorine contents in organs and tissues were also reduced in effective cases. 8) The mode of effective action of adrenochrome and sodium arsenate is not clear at present. From the results above mentioned, it may be concluded that the best method of treatment will be the combination of ethanol with acetamide or monoacetin as acetate-donor, procain amide against the ventricular fibrillation, and orotic acid (B_<13>) for detoxication.
- 社団法人日本産業衛生学会の論文