臓器組織と鉛との結合状態に関する実験的研究 : Ca-EDTAの応用

概要

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By a previous author in our department, an experimental study had been made on the state of combination of lead in blood, applying the chelating action of Edathamil. In this study, the present author performed a similar experiment on organ-homogenates such as of liver, brain, lung, muscle, etc., in order to make overt the difference of combining affinity with lead by variable organs. The following conclusions were reached by the experiment. 1) In the liver of normal rabbits, there is such relation between the dose of added lead and the composition of Pb-EDTA as is expressed by an equation: y=4.70x^<0.84>, where y=dose of added, x=lead amount of Pb-EDTA. 2) The added lead into organ-homogenates of normal rabbits in vitro is combined with bone and liver more firmly than with brain or lung. 3) Lead in organs of rabbits with chronic lead poisoning is more stable to be combined, compared with lead in those with acute lead poisoning. 4) The different state of lead combination with variable organs or the difference of affinity with lead by organ is not only attributed to the different chemical property of water non-soluble protein, but might also be due to water soluble protein and other biological factors which are not detected by the present experiment.
社団法人日本産業衛生学会の論文