チオクト酸のフリッカー値, 膝蓋腱反射閾値並びに視覚反応時間値に及ぼす影響

概要

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The influence of thioctic acid on fatigue was studied, using 41 male employees as the subjects. The flicker value, the threshold of patellar reflex and the reaction time to light were measured on 7 consecutive work days. The acid, 20 mg. a 〓y, was given to each of the nearly half of the subjects, while to the rest members placeboes were given. The means, caluculated from each set of observations, showed the following trends: 1. Flicker value. The acid was able to chek the daily lowering, which happens unavoidably under usual state, and there was on the whole a sign of lesser diurnal lowerings. 2. Patellar reflex. The threshold of the reflex showed similar effects like those seen in the flicker value. 3. Reaction time to light. The effects of the acid administration were very much obscure; yet one perceives an improvement of the reaction on the administered group. 4. For those subjects working the night shift the effects were remarkable. One may conclude from these observations that thioctic acid is effective to prevent fatigue, notably of the cumulative form.
社団法人日本産業衛生学会の論文