肺結核再発及び珪肺結核に対するINHG予防内服の効果について
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During these four years the authors have examined the prophylactic chemotherapy by INHG, on 128 patients who are thought as recovered from pulmonary tuberculosis, and on 24 patient under surveillance suspected of silicotuberculosis, at Hosokura Mine. The following results have been obtained. 1. In the X-ray observation 8.7 per cent of of 128 patients showed some improvement, no change for 89.0 per cent, and aggravation for 2.3 per cent. 2. The improvement rate was highest in the nodular type (28.6%), and secondary infiltrated caseous type (25.0%) fibrocaseous type (7.7%) followed in the order of improvement. 3. As to the term of improvement, 64.0 per cent of improvement cases were observed within 12 months and 27.0 per cent in further 6 months. 4. It could be recognized that some effect as regards the erythrocyte sedimentation rate, it's improvement rate was 22.7 per cent and it's aggravation rate was 5.5 per cent. 5. There was no significant effect in other physical examination results: body weight, vital capacity and tubecle bacilli in the sputum. 6. During the prophylactic chemotherapy of INHG, harmful subjective symptoms such as anorexia or constipation were observed in 11.0 per cent of the cases. But those complaints were so slight that no case had to discontinue the use of INHG. 7. Owing to this prophylactic chemotherapy, the recrudescent cases of pulmonary tuberculosis have diminished year by year since it's beginning, 1955. 8. The recrudescent cases of pulmonary tuberculosis for three years before and after the start of this examination decreased from 17 to 5. 9. On 24 patients under surveillance suspected of silicotuberculosis, in spite of long term prophylactic chemotherapy of INHG (over two years), there was no case of improvement but three cases of aggravation. The aggravation rate was 12.5 per cent and was considerably high compared with that of pulmonary tuberculosis, but was diminished to one third compared with the same group before three years and the degree of the aggravation also became so slight that it could be conjectured that some effect of this prophylactic chemotherapy on this group. 10. In other results by physical examinations, especially the decrease of vital capacity was distinguishied; 42.0 per cent of the cases were found as such. In view of the observation above described, the prophylactic chemotherapy of INHG showed some usefulness in the health administration of the persons under surveillance suspected of pulmonary tuberculosis and silicotuberculosis. On account of this usefulness, the prophylactic chemotherapy should be recommended more and more for the administration of those patients rather than limiting of labour conditions or mere follow-up observation. However, such conculsion on silicotuberculosis should be modestly accepted, because the term observed is not long enough and the number of patients examined is neither satisfactory.
- 社団法人日本産業衛生学会の論文
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