各種珪酸塵の塵肺生起能に関する実験的研究
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概要
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Dusts of various silicious compounds, such as muscovite, chlorite, tourmalin, beryl, topaz, wallastonite, talc, epidote, orthoclase, diopside, yttrialite, bustamite and gadolinite as well as those of alpha-quartz and coal were prepared in size of three microns and less, and they were ascertained of their purity through the X-ray diffraction method. Each of these dusts, in amounts of 10 mg and 50 mg respectively, was introduced into the trachea of rats, and changes in the lung and thoracic lymphatic glands were examined two, four and six months after the introduction. In the case of talc dust, although formation of glanulomatous nodes in the lung was marked, that of fibrosis was not confirmed, and changes in the thoracic lymphatic glands were very slight. In cases of silicates with radioactivity (yttrialite, gadolinite, and bustamite), fibrogenetic changes were observed in a wide field of the lung, and slight fibrosis was confirmed in the thoracic lymphatic glands. Dusts of epitode, which contained alpha-quartz in 36 per cent, caused slight changes of silicosis. Dusts of other silicates, in general, introduced in an amount of 10 mg, caused merely changes similar to those by coal dust, while through introduction in an amount of 50 mg most of them caused strong fibrogenetic changes, especially muscovite and biotite. In these cases, changes in the thoracic lymphatic glands were rather more marked than those by the coal dust, but they were not of such typical fibrosis as found in the case of alpha-quartz.
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