Metabolism of Terbufos in Rat Liver

概要

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Biotransformation of terbufos in rat liver revealed four metabolites in the effluent prepared with a C_<18> cartridge after the rat liver was perfused for one hour in situ. Analysing the spectrogram of GC-IR and GC-MS, metabolite IV appeared to be an oxidative desulfuration product of terbufos with the formula C_9H_<21>O_3PS_2, the recovery of which in the effluent was 2.13%; metabolite I appeared to be an hydrolysate of metabolite IV with the formula C_5H_<13>O_3PS, the recovery of which was 0.13%; metabolite II appeared to be an hydrolysate of terbufos with the formula C_5H_<13>O_2PS_2, the recovery of which was 2.65%; metabolite III appeared to be a methylate of metabolite II, with the formula C_6H_<15>O_2PS_2, the recovery of which was 1.42%. Relatively the recovery of terbufos was 40.8%. These results were in accord with the regular metabolic pattern in vivo of phosphorothioates with a thioether group.
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