Effect of Chlordimeform on Cardiovascular Function in Occupational Exposures

概要

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To understand the possible effects of an insecticide, chlordimeform, on the human cardiovascular system, this work was carried out. Pre- and post-exposure, the medical examinations, especially cardiovascular functions, were meticulously done in farmers spraying 0.125% solution of chlordimeforme for 3 consecutive days and packers packing chlordimeform for one month. The exposure level was measured by means of the urinary excretion of chlordimeform and its main metabolite, 4-chlor-o-tolumidine, as well as the air concentration in the work place and skin contamination by using a regional proportional sampling strategy. The alterations, though mild and diverse, were significant compared to their own pre-exposure background. The changes in heart rate, blood pressure and some EKG parameters, such as T wave, P wave, PR interval and Qt interval were noticed. The cardiovascular functional changes were usual and sensitive findings in the exposed persons, and their importance in health surveillance needs to be emphasized.
社団法人日本産業衛生学会の論文