Screening of Helicobacter Pylori Infection in the Health Examination Detected by Urea Breath Test and Barium Meal Study

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概要

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• Screening of Helicobacter Pylori Infection in the Health Examination Detected by Urea Breath Test and Barium Meal Study : Fumihiro YAMASAWA, et al. Marubeni Clinic-Background : Helicobacter pylori, H.pylori, is now assumed to be a definite cause of gastric cancer. Health examinations for the early detection of atherosclerotic diseases and malignant diseases have been widely undertakeh in Japan, where the incidence of gastric cancer is still one of the highest in the world. To investigate H. pylori infection non-invasively in the regular health examinations, we introduced the urea breath test (UBT) with a barium meal study in the ordinary system. Methods : Sixty male subjects were studied (mean age : 47.8 y/o) in this study. After blood examination for anti H. pylori lgG antibody, the reference expired gas was collected from each subject. Then the subject took 100 mg of ^<13>C-urea dissolved in water with tartaric acid and sodium bicarbonate, which was used to distend the stomech, and an ordinary barum meal study was undertaken. Several rotations of the body were added to subjects for fluoroscopy. Thirty minutes after ^<13>C-urea intake, the expired gas was collected again as the second gas sample. The ratio of ^<13>C to ^<12>C in the reference and second expired gas sample was measured with a mass spectromenter and the changed fraction of the isotope concentration, d, was calculated in each subject. The X-ray films of the barium meal study were read independently by one roentgenologist who was not informed at all about this study. Cases were divided into 2 groups : one group without mucosal inflammatory diseases and another group with mucosal inflammatory diseases. Results : The d value for subjects with positive H. Pylori antibody and with mucosal inflamatory diseases, who were strongly suggestive of positive H.pylori infection, had a significantly higher value (d:2.492±1.372, p<0.001) than that for subjects with negative H.pylori antibody and without mucosal inflammatory diseases, who were thought not to have H.pylori infection (d:0.141±0.107). Subjects who were strongly suggestive of H.pylori infection showed distinctly higner value. Conclusions : Barium did not interfere with the reaction of H. pylori and ^<13>C-urea in the gastric mucosa. UBT can be performed non-invasively together with a barium meal study and it provides usuful information on H. pylori infection in the health examination.

• 社団法人日本産業衛生学会の論文

著者

• ICHINOSE Yuichi

  the First Department of Internal Medicine Tokyo Medical College

• Kanai Emiko

  First Department Of Internal Medicine Tokyo Medical College

• Toyama Keisuke

  Westron Co.

• Yonemaru Makoto

  First Department Of Internal Medicine Tokyo Medical College

• Ichinose Yuichi

  First Department Of Internal Medicine Tokyo Medical College

• YAMASAWA Fumihiro

  Marubeni Clinic

• Yonemura Makoto

  The First Department Of Internal Medicine Tokyo Medical College

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