Serum Oxidant and Antioxidant Levels in Diesel Exposed Toll Collectors

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概要

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• It has been suggested that exposure to diesel exhaust may lead to adverse effects due to the generation of oxidants. To evaluate the end products of oxidative stress in DE exposure, toll collectors who are considered a high risk group in regard to occupational toxins were compared to controls who had office-based occupations in the same company in this cross sectional study. A total of 38 toll collectors constituted the study group. All subjects were male. The toll collectors and 29 controls were similar regarding age, smoking status and duration of work. All subjects underwent a clinical examination and an interviewer-administrated questionnaire regarding respiratory symptoms, past medical and occupational history, and pulmonary function tests were performed in all subjects. Serum malondialdehyde (MDA), nitrite+nitrate and vitamin E levels were measured. Toll collectors showed higher serum MDA (5.76 ± 2.15 μmol/L vs. 3.07 ± 0.76 μmol/L, p=0.0001) and nitrite+nitrate levels (96.50 ± 45.54 μmol/L vs. 19.32 ± 11.77 μmol/L, p=0.0001) than controls. Vitamin E levels were similar in toll collectors and controls (10.57 ± 3.44 mg/L and 9.72 ± 2.44 mg/L, respectively, p=0.267). There was no difference between groups in terms of the findings of clinical examinations and respiratory symptoms. In pulmonary function parameters, only peak expiratory flow (PEF) in toll collectors was significantly lower than that of controls (88.9% predicted and 104.2% predicted, respectively, p=0.012). In conclusion, we suggest that serum MDA and nitrite+nitrate levels may be used as biological markers of oxidative stress related to DE exposure, but prospective controlled clinical studies are necessary to clarify the possible association between concentrations of MDA and nitrite+nitrate and pulmonary diseases related to DE exposure. (J Occup Health 2004 ; 46 : 281-288)

• 社団法人日本産業衛生学会の論文

著者

• YAVUZ Ozlem

  Department of Biochemistry, Abant Izzet Baysal University Hospital

• ARBAK Peri

  Department of Chest Diseases, Abant Izzet Baysal University, Duzce School of Medicine

• BUKAN Neslihan

  Department of Biochemistry, Gazi University, School of Medicine

• BALBAY Oner

  Department of Chest Diseases, Abant Izzet Baysal University, Duzce School of Medicine

• ULGER Fusun

  Department of Chest Diseases, Ankara University, School of Medicine

• ANNAKKAYA Ali

  Department of Chest Diseases, Abant Izzet Baysal University, Duzce School of Medicine

• Ulger Fusun

  Department Of Chest Diseases Ankara University School Of Medicine

• Yavuz Ozlem

  Department Of Biochemistry Abant Izzet Baysal University Hospital

• Yavuz Ozlem

  Department Of Biochemistry Abant Izzet Baysal University Duzce School Of Medicine

• Annakkaya Ali

  Fac. Of Medicine Dep. Of Chest Diseases Duzce Univ.

• Bukan N

  Gazi Univ. Ankara Tur

• Bukan Neslihan

  Department Of Biochemistry University Of Gazi

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