Occupational Exposure to Aromatic Hydrocarbons at a Coke Plant : Part I. Identification of Hydrocarbons in Air and their Metabolites in Urine by a Gas Chromatography-Mass Spectrometry Method

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概要

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• A method for the qualitative analysis of aromatic hydrocarbons in air and their various urinary metabolites is presented. The air was sampled in charcoal tubes and extracted with carbon disulfide. The hydrocarbons were identified as being aliphatic hydrocarbons (C_9-C_<19>), aromatic hydrocarbons and heterocyclic compounds. The urinary metabolites after enzymatic hydrolysis were analyzed by solid-phase extraction with a styrenedivinylbenzene resin, silylation with N,O-bis(trimethylsilyl)acetamide and GC/MS for separation and detection. Satisfactory separation of all compounds investigated was achieved without interference due to matrix peaks. The following compounds were identified in the urine of workers : dimethylphenol isomers, 4-ethyl-1,3-benzenediol, 2-ethoxybenzoic acid and methoxyphenols. Trimethylsilyl derivatives of aromatic hydroxyacids and hydroxymethoxyacids were found in the urine of occupationally exposed workers by means of a silylation procedure.

• 社団法人日本産業衛生学会の論文

著者

• Wilczok Tadeusz

  Department Of Molecular Biology Biochemistry And Biopharmacy Faculty Of Pharmacy Medical University

• BIENIEK Grazyna

  Department of Molecular Biology, Biochemistry and Biopharmacy, Faculty of Pharmacy Medical Universit

• KURKIEWICZ Slawomir

  Department of Molecular Biology, Biochemistry and Biopharmacy, Faculty of Pharmacy Medical Universit

• Bieniek G

  Dep. Of Instrumental Analysis Fac. Of Pharmacy Medical Univ. Of Silesia

• Bieniek Grazyna

  Department Of Biochemistry And Biophysics Silesian Medical Academy

• Kurkiewicz Slawomir

  Department Of Molecular Biology Biochemistry And Biopharmacy Faculty Of Pharmacy Medical University

関連論文

• Occupational Exposure to Aromatic Hydrocarbons at a Coke Plant : Part II. Exposure Assessment of Volatile Organic Compounds
• Occupational Exposure to Aromatic Hydrocarbons at a Coke Plant : Part I. Identification of Hydrocarbons in Air and their Metabolites in Urine by a Gas Chromatography-Mass Spectrometry Method
• Simultaneous determination of phenol, cresol, xylenol isomers and naphthols in urine by capillary gas chromatography
• Simultaneous determination of 2-methoxyphenol, 2-methoxy-4-methylphenol, 2,6-dimethoxyphenol and 4'-hydroxy-3'-methoxyacetophenone in urine by capillary gas chromatography
• Occupational Exposure to Phenolic Compounds at Coke Plants-Urinary Excretion of Methoxyphenols as an Indicator of Exposure to Methoxyphenols

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