Lipid Peroxidation Induced by NAD(P)H and NAD^+-Dependent Substrates in Soybean Mitochondria

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概要

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• Lipid peroxidation induced by Fe^<2+>/ADP in soybean mitochondria is stimulated by pyruvate, malate (in the presence of NAD^+) and by NAD(P)H. This lipid peroxidation is almost completely inhibited by EDTA indicating that iron is essential. Also salicylhydroxamic acid, a specific inhibitor of the alternate oxidase, is a strong inhibitor of lipid peroxidation but its effect should be related to chelation or to a general antioxidant action. Rotenone does not show any effect on the malate/NAD^+/Fe^<2+>/ADP-induced lipid peroxidation. From the reported data, it is possible to conclude that, in soybean mitochondria, the peroxidation of unsaturated lipids can be modulated through a balance between the systems sparking lipid peroxidation, like NAD(P)H/Fe^<2+>/ADP, and the systems which protect against it, i.e. quinones, maintained at the reduced state by the substrates.

• 日本植物生理学会の論文

著者

• Vianello A

  Dipartimento Di Biologia Ed Economia Agro-industriale Sezione Di Biologia Vegetale Universita Udine

• Macri Francesco

  Section Of Plant Physiology And Biochemistry Institute Of Plant Protection University Of Udine

• Vianello Angelo

  Section of Plant Physiology and Biochemistry, Institute of Plant Protection, University of Udine

• Bindoli Alberto

  Centre for the Study of Mitochondrial Physiology, C. N. R., I-35100 Padova and Institute of Biologic

• Bindoli Alberto

  Centre For The Study Of Mitochondrial Physiology C. N. R. I-35100 Padova And Institute Of Biological

関連論文

• ATP Synthesis Driven by a-Keto Acid-stimulated Alternative Oxidase in Pea Leaf Mitochondria
• Orientation of Pea Stem Mitochondrial H^+-pyrophosphatase and Its Different Characteristics from the Tonoplast Counterpart
• Lipid Peroxidation Induced by NAD(P)H and NAD^+-Dependent Substrates in Soybean Mitochondria

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