Phosphorylation of Chromosomal Proteins Changes during the Development of Crown Gall Tumors

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Crown gall tumors were initiated on potato tuber nurse tissue by Agrobacterium tumefaciens, strain C58. Tumorous protuberances appeared some 5-8 days after infection and grew to knob-like tumors in 3-5 weeks, after which proliferation diminished continuously and then ceased in old tumors. Synthesis of RNA increased dramatically in growing tumors as did the activity of both chromatin-bound DNA-dependent RNA polymerases I and II. Chromatin-bound protein kinases accepting endogenous proteins, phosvitin, casein or histones were activated concomitantly, leading to higher phosphory-lation rates of chromatin proteins during tumor development. With the transition of a normal, wounded cell into a transformed cell, the chromosomal protein pattern changed and then remained unchanged throughout tumor growth and senescence. In contrast, the phosphorylation pattern of these proteins was highly stage-specific.
日本植物生理学会の論文