The possible role of cyclic AMP in the control of genetic tumor induction
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概要
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Young seedlings of the tumor-prone amphiploid Nicotiana suaveolens × N. langsdorffii, grown aseptically on nutrient medium, were treated with 1 × 10^<-2> M cyclic adenosine 3':5'-monophosphate (cyclic AMP). The incidence of tumor formation was scored at regular intervals subsequent to exposure. Cyclic AMP caused a significant reduction in the rate of tumor formation. In addition, untreated plants grown on nutrient medium were harvested at regular intervals after the seeds had been sown. Cyclic AMP was extracted, partially purified, and assayed radioimmunologically. The endogenous level of cyclic AMP in stem tissue was highest in young seedlings, rapidly fell reaching a low point in 18 day-old plants, and eventually leveled off. The presence of indoleacetic acid (IAA) in the growth medium at a final concentration of 2 × 10^<-5> M prevented the decline in cyclic AMP that occurred in seedlings grown on unsupplemented medium.
- 日本植物生理学会の論文