Free D-Aspartate in Mammals(D-Amino Acid Biosystem)
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概要
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D-Aspartate (D-Asp) is an endogenous amino acid present in nervous and endocrine tissues in mammals. A high concentration of D-Asp is observed in embryos, which disappears in nervous tissues after delivery, but increases temporarily in endocrine glands, particularly in the pituitary, pineal and adrenal glands at the specific stages. In the pineal gland, D-Asp that is apparently derived from other tissues suppresses melatonin secretion from parenchymal cells. Additionally, D-Asp levels increase in the testis just before birth and during maturation. The amino acid is presumed to be synthesized by the pituitary gland and testis. In the testis, D-Asp produced inside the seminiferous tubules acts on Leydig cells following release to enhance testosterone synthesis by activating the expression of Steroidogenic Acute Regulatory protein. Mammalian cells appear to contain all the molecular components required to regulate D-Asp homeostasis, as they can synthesize, release, take up, and degrade the amino acid. These findings collectively indicate that D-Asp is a novel type of messenger in the mammalian body.
- 公益社団法人日本薬学会の論文
- 2005-09-01
著者
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FURUCHI TAKEMITSU
Laboratory of Molecular and Biochemical Toxicology, Graduate School of Pharmaceutical Sciences, Toho
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Hamamoto Hiroshi
Laboratory Of Microbiology Graduate School Of Pharmaceutical Sciences The University Of Tokyo
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Homma Hiroshi
Laboratory Of Microbiology Graduate School Of Pharmaceutical Sciences The University Of Tokyo
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Furuchi Takemitsu
Laboratory Of Biomolecular Science School Of Pharmaceutical Sciences Kitasato University
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