Quantitative Evaluation of Effect of Renal Failure on the Pharmacokinetics of Panipenem in Rats(Biopharmacy)

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概要

• 論文の詳細を見る

• The pharmacokinetics of panipenem in experimental renal failure animal models was investigated in order to identify the appropriate covariates affecting the pharmacokinetic behavior. Panipenem and betamipron were administered intravenously to rats with a variety of renal failures, such as nephritis induced by glycerol, gentamicin, uranium and antiserum against glomerular basement membrane as well as 5/6 subtotal nephrectomy. Panipenem in plasma and urine was determined and pharmacokinetic analysis was performed using a one-compartment open model. The elimination half-life prolonged and total body clearance, renal clearance (CL_R) and renal excretion ratio were decreased according to the renal function, i.e. control>glycerol>anti-GBM=gentamicin>nephrectomy=uranium in order. However, distribution volume was consistent in all models. CL_R showed strong positive correlation with the glomerular filtration rate in spite of a weak correlation with the reciprocal of blood urea nitrogen. However, no obvious correlation was observed with secretory clearance of N-1-methylnicotinamide. This preliminary information based on animal model might be useful for designing pharmacokinetic studies in special population at early stage of new drug development.

• 公益社団法人日本薬学会の論文
• 2005-11-01

著者

• Naganuma Hideo

  横浜市立大学 第2内科

• Naganuma Hideo

  Clinical Pharmacology And Biostatistics Department

• Naganuma Hideo

  三共

• TAJIMA Naoyuki

  Clinical Pharmacology and Biostatistics Department

• Tajima Naoyuki

  Clinical Pharmacology And Biostatistics Department Sankyo Co. Ltd.

• SOMA Masako

  Drug Metabolism and Pharmacokinetics Research Laboratories, Sankyo Co., Ltd.

• ISHIZUKA Hitoshi

  Clinical Pharmacology and Biostatistics Department, Sankyo Co., Ltd.

• Soma Masako

  Drug Metabolism And Pharmacokinetics Research Laboratories Sankyo Co. Ltd.

• Ishizuka Hitoshi

  Clinical Pharmacology And Biostatistics Department Sankyo Co. Ltd.

• Ishizuka Hitoshi

  Clinical Pharmacology And Biostatistics Dep. Sankyo Co. Ltd.

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• Quantitative Evaluation of Effect of Renal Failure on the Pharmacokinetics of Panipenem in Rats(Biopharmacy)
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