Design, Synthesis, and Structure-Activity Relationships of 3,4-Dihydropyridopyrimidin-2(1H)-one Derivatives as a Novel Class of Sodium/Calcium Exchanger Inhibitor
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概要
- 論文の詳細を見る
Design, synthesis, and structure-activity relationships for 3,4-dihydropyridopyrimidin-2(1H)-one derivatives, which are aza-3,4-dihydro-2(1H)-quinazolinone derivatives, as the sodium/calcium (Na^+/Ca^<2+>) exchanger inhibitors are discussed. These studies based on 3,4-dihydro-2(1H)-quinazolinone derivatives led to the discovery of a structurally novel and potent Na^+/Ca^<2+> exchanger inhibitor, 3,4-dihydropyridopyrimidin-2(1H)-one derivative (26), with an IC_<30> value of 0.02μM. Compound 26 directly inhibited the Na^+-dependent Ca^<2+> influx via the Na^+/Ca^<2+> exchanger after Na^+-free treatment in cardiomyocytes.
- 公益社団法人日本薬学会の論文
- 2005-10-01
著者
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Kojima Atsuyuki
Takarazuka Organic Synthesis Department Sumika Technoservice Co. Ltd.
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Hasegawa Hirohiko
Research Division Sumitomo Pharmaceuticals Co. Ltd.
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MURAOKA Masami
Research Division, Sumitomo Pharmaceuticals Co., Ltd.
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OHMORI Mikiko
Research Division, Sumitomo Pharmaceuticals Co., Ltd.
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MATSUI Kazuki
Research Division, Sumitomo Pharmaceuticals Co., Ltd.
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Matsui Kazuki
Research Division Sumitomo Pharmaceuticals Co. Ltd.
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Matsui Kazuki
Research Center Sumitomo Pharmaceuticals Co. Ltd
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Ohmori Mikiko
Research Division Sumitomo Pharmaceuticals Co. Ltd.
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Muraoka Masami
Research Division Sumitomo Pharmaceuticals Co. Ltd.
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