イミン類への炭素ラジカル付加反応の開発

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概要

• 論文の詳細を見る

• This review summarizes the new carbon-carbon bond construction methods based on the radical reaction of imine derivatives. The intermolecular carbon radical addition to oxime ethers proceeded smoothly in the presence of BF3・ OEt2. A high degree of stereocontrol in the reaction of oxime ethers was achieved to give amino acid derivatives with excellent diastereoselectivities. The radical reaction of imine derivatives in water has also been investigated. The radical cyclization of oxime ethers proceeded effectively to provide the functionalized heterocycles via a carbon-carbon bondforming process. These reactions were extended to the solid-phase radical reactions using triethylborane or diethylzinc as a radical initiator.

• 公益社団法人日本薬学会の論文
• 2003-05-01

著者

• 宮部 豪人

  京都大学大学院薬学研究科

関連論文

• インジウムを用いた水溶媒中炭素-炭素結合形成反応の開発 (環境をめぐる視点(2))
• イミン類への炭素ラジカル付加反応の開発

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