Effects of Propolis on Hypoxanthine-Xanthine Oxidase-Induced Toxicity in Cultivated Human Cells and on Neutrophil Elastase Activity(Pharmacology)

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概要

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• The inhibition of the proliferation rate of the immortalized human cell line ECV 304 after oxidant damage by oxygen radicals generated in a hypoxanthin-xanthine oxidase system and the protection provided by various propolis extracts was determined. Best inhibition was demonstrated by 60-80% ethanolic extracts (IC_<50> of approximately 2μg dry weight/ml) and by the ethyl acetate extract (IC_<50> of 6.9μg dry weight/ml). The beneficial effect of polar extracts was quite weak. Human neutrophil elastase activity was inhibited distinctively by ethanolic (60 to 96%) and ethyl acetate extracts (IC_<50> of approximately 2μg dry weight/ml). Both activities seem to be responsible for the anti-inflammatory effect of the extract.

• 公益社団法人日本薬学会の論文
• 2005-07-01

著者

• Melzig Matthias

  Institut Fur Pharmazie Freie Universitat Berlin

• BEYER Gaby

  Institut fur Biologie, Biochemie der Pflanzen, Humboldt-Universitat zu Berlin

• Beyer Gaby

  Institut Fur Biologie Biochemie Der Pflanzen Humboldt-universitat Zu Berlin

関連論文

• A convenient method for saponin isolation in tumour therapy
• Effects of Propolis on Hypoxanthine-Xanthine Oxidase-Induced Toxicity in Cultivated Human Cells and on Neutrophil Elastase Activity(Pharmacology)

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