Inhibitory Effects of the Flavonoids Isolated from Waltheria indica on the Production of NO, TNF-α and IL-12 in Activated Macrophages(Pharmacology)

スポンサーリンク

概要

• 論文の詳細を見る

• Three flavonoids were isolated from the whole plants of Waltheria indica and biological properties investigated. On the basis of their spectroscopic data, these compounds were identified as (-)-epicatechin, quercetin, and tiliroside. These flavonoids significantly and dose-dependently inhibited the production of the inflammatory mediator nitric oxide (NO), and the cytokines (tumor necrosis factor (TNF)-α and interleukin (IL)-12), in lipopolysaccharide (LPS) and interferon (IFN)-γ activated murine peritoneal macrophages, without displaying cytotoxicity. The order of inhibitory activity was quercetin>tiliroside>(-)-epicatechin. Furthermore, peritoneal macrophages were pre-activated with LPS/IFN-γ for 24h, and the inhibitory effects of the above mentioned isolates on the production of NO were determined after a further 24h, to address the possible mechanisms of their action. The present study supports the use of W. indica for the treatment of inflammatory diseases in traditional medicine.

• 公益社団法人日本薬学会の論文
• 2005-05-01

著者

• Rao Yerra

  Institute Of Biotechnology Chaoyang University Of Technology

• Tzeng Yew

  Institute Of Biotechnology Chaoyang University Of Technology

• FANG Shih

  Department of Microbiology, School of Medicine, China Medical University

• Fang Shih

  Department Of Microbiology School Of Medicine China Medical University

• Fang Shih-Hua

  Department of Microbiology, School of Medicine, China Medical University

• Tzeng Yew-Min

  Institute of Biotechnology, Chaoyang University of Technology

関連論文

• A New Highly Oxygenated Pseudoguaianolide from a Collection of the Flowers of Parthenium hysterophorus
• Inhibitory Effects of the Flavonoids Isolated from Waltheria indica on the Production of NO, TNF-α and IL-12 in Activated Macrophages(Pharmacology)

スポンサーリンク