Experimental Analysis of Antimicrobial Action of Dicyclomine Hydrochloride(Miscellaneous)
スポンサーリンク
概要
- 論文の詳細を見る
Dicyclomine hydrochloride is an antispasmodic agent. The MIC of dicyclomine against standard strains of Gram positive and Gram negative bacteria were performed by NCCLS broth dilution technique. These drugs showed a rapid killing action on Gram positive bacteria, Staphylococcus aureus NCTC 6571, 8530 and several other reference strains. The killing effect against Gram negative bacteria, Shigella boydii 8 NCTC 254/66 and Salmonella typhimurium NCTC 74 showed that the drug was bacteriostatic with respect to these strains. High rate of killing was achieved for most strains of Gram positive bacteria within 2 h. When administered to Swiss strain of white mice at doses of 30 and 60 μg/g of mouse, the drug could significantly protect the animals challenged with 50 MLD of Salmonella typhimurium NCTC 74. According to X^2 test, the in vivo data were highly significant (p<0.001). Since dicyclomine showed a remarkable inhibitory action against several pathogenic bacteria, in the course of time, it may be developed as a potent antimicrobial agent for many bacterial infections.
- 公益社団法人日本薬学会の論文
- 2004-12-01
著者
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Dastidar Sujata
Division Of Microbiology Department Of Pharmaceutical Technology Jadavpur University
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Dastidar Sujata
Division Of Microbiology Department Of Pharmaceutical
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Basu Laxmi
Division Of Microbiology Department Of Pharmaceutical Technology Jadavpur University
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KUMAR Kuppusamy
Division of Microbiology, Department of Pharmaceutical Technology, Jadavpur University
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RAY Raja
Department of Medical Microbiology & Parasitology, Calcutta University
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Ray Raja
Department Of Medical Microbiology & Parasitology Calcutta University
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Kumar Kuppusamy
Division Of Microbiology Department Of Pharmaceutical Technology Jadavpur University
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KARAKA Prithviraj
Division of Microbiology, Department of Pharmaceutical Technology, Jadavpur University
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DASGUPTA Asish
Division of Microbiology, Department of Pharmaceutical Technology, Jadavpur University
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Dasgupta Asish
Division Of Microbiology Department Of Pharmaceutical Technology Jadavpur University
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Karaka Prithviraj
Division Of Microbiology Department Of Pharmaceutical Technology Jadavpur University
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Asok Kumal
Division of Microbiology, Department of Pharmaceutical Technology, Jadavpur University
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DASTIDAR Sujata
Division of Microbiology, Department of Pharmaceutical Technology, Jadavpur University
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