Spectrophotometric Determination of Hydroxylamine and Its Derivatives in Pharmaceuticals

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概要

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• A sensitive spectrophotometric method for the determination of hydroxylamine is described. The method is based on the oxidation of hydroxylamine to nitrite using sodium arsenate under alkaline condition. The formed nitrite is determined based on the diazo coupling reaction between p-nitroaniline and N- (1-naphthyl) ethylenediamine dihydrochloride [NEDA]. The system obeys Beer's law over the concentration range 0-7μg of hydroxylamine at 545 nm and the colour is stable for 3 h. The molar absorptivity of the colour system is found to be 6.7×10^4lmol^<-1>cm^<-1>. The relative standard deviation is 1.2% for ten determinations at 4μg of hydroxylamine. Interferences due to various foreign ions have been studied and the method has been applied to the determination of hydroxylamine and its derivatives used in pharmaceutical formulations after hydrolysis.

• 公益社団法人日本薬学会の論文
• 2004-12-01

著者

• Balasubramanian Natesan

  Department Of Chemistry Indian Institute Of Technology

• Nagaraja Karachalacherevu

  Department Of Chemistry Loyola Institute Of Frontier Energy (life) Loyola College

• Deepa Boppana

  Department Of Chemistry Loyola Institute Of Frontier Energy (life) Loyola College

関連論文

• Indirect Spectrophotometric Determination of Thiamine in Pharmaceutical Preparations
• Spectrophotometric Determination of Iodine Species in Table Salt and Pharmaceutical Preparations
• Spectrophotometric Determination of Hydroxylamine and Its Derivatives in Pharmaceuticals
• Spectrophotometric Determination of Nanogram Amounts of Tin after Extraction from Iodide Media

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