Matrix Metalloproteinase-1 Inhibitor from the Stem Bark of Styrax japonica S. et Z.
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概要
- 論文の詳細を見る
A bioassay-guided fractionation of the ethyl acetate soluble fraction from the stem bark of Styrax japonica S. et Z. (Styracaceae) yielded two new lignan compounds, styraxjaponoside A (1) and styraxjaponoside B (2), along with three known compounds, matairesinoside (3), egonol glucoside (4), and dihydrodehydrodiconiferyl alcohol 9'-O-glucoside (5). The structures of compounds 1-5 were determined by spectroscopic method, as well as 1D- and 2D-NMR (HSQC, ^1H COSY, and HMBC) spectroscopy. Among them, compound 2 exhibited potent inhibitory activity against matrix metalloproteinase (MMP) -1, and prevented the UV-induced changes in the MMP-1 expression. In addition, compounds 3 and 5 were isolated from this plant for the first time.
- 公益社団法人日本薬学会の論文
- 2004-12-01
著者
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HAHM Kyung-Soo
Research Center for Proteineous Materials (RCPM)
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Hahm Kyung-soo
Research Center For Proteineous Materials Chosun University
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Kim Mi-ran
Research Center For Proteineous Materials Chosun University
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Moon Hyung-in
Clinical Research Institute College Of Medicine Seoul National University
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Chung Jin
Clinical Research Institute College Of Medicine Seoul National University
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Woo Eun-rhan
Research Center For Proteineous Materials Chosun University:college Of Pharmacy Chosun University
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MOON Young
College of Pharmacy, Chosun University
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Moon Young
College Of Pharmacy Chosun University
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