Nucleosides XI. Synthesis and Antiviral Evaluation of 5'-Alkylthio-5'-deoxy Quinazolinone Nucleoside Derivatives as S-Adenosyl-L-homocysteine Analogs

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概要

• 論文の詳細を見る

• 4-Amino-1- (β-_D-ribofuranosyl) quinazolin-2-one (3) was prepared by a direct glycosylation of 4-aminoquinazolin-2-one (7) using the Vorbruggen's silylation method and provided exclusively the β-anomer. This quinazoline nucleoside and its 2', 3'-O-isopropylidene derivative (9) did not undergo the coupling reaction with dialkyl disulfides in the presence of tri-n-butylphosphine unless their 4-amino groups were protected by N, N-dimethyl-aminomethylidene. This approach provides a viable alternative synthetic route to 5'-alkylthio-5'-deoxy nucleosides.

• 公益社団法人日本薬学会の論文
• 2004-12-01

著者

• Chern Ji-wang

  School Of Pharmacy College Of Medicine National Taiwan University No. 1 Section 1

• Chen Chien-shu

  School Of Pharmacy College Of Medicine National Taiwan University No. 1 Section 1

• Chien T‐c

  School Of Pharmacy College Of Medicine National Taiwan University No. 1 Section 1

• CHIEN Tun-Cheng

  School of Pharmacy, College of Medicine, National Taiwan University No. 1, Section 1

• YU Fang-Hwa

  School of Pharmacy, College of Medicine, National Taiwan University No. 1, Section 1

• Yu Fang-hwa

  School Of Pharmacy College Of Medicine National Taiwan University No. 1 Section 1

関連論文

• Studies on Quinazolines. VII. Reactions of Anthranilamide with β-Diketones; New Approaches toward the Synthesis of Tetrahydropyrido[2,1-b]quinazolin-11-one Derivatives
• Nucleosides XI. Synthesis and Antiviral Evaluation of 5'-Alkylthio-5'-deoxy Quinazolinone Nucleoside Derivatives as S-Adenosyl-L-homocysteine Analogs

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