Pharmacological Effects of Elenoside, an Arylnaphthalene Lignan

概要

論文の詳細を見る
Acute toxicity(24h)and general behavior in mice of a lignan from Justicia hyssopifolia, a β-_D-gluvoside(elenoside), was studied, and the cytotoxic activity was performed. Elenoside(arylnaphthalene lignan)in mice showed a moderate toxicity order(305mg/kg)and central depressive properties at doses of 25, 50, and 100mg/kg. It aoso displayed cytotoxic activity in a range of concentration of 10^<-5>-10^<-4>м when studied in the human tumor cell lice panel of the US National Cancer Institute(NCI). The results indicated that elenoside has central depressant effects, and the cytotoxic activity of elenoside suggests that this compound and its genin derivatives merit further investigation as antiumoral drugs.
公益社団法人日本薬学会の論文
2001-03-01