Antioxidant Activities of Buckwhat Hull Extract toward Various Oxidative Stress in Vitro and in Vivo

概要

論文の詳細を見る
We have undertaken four basic in vitro studies and an animal experiment to obtain information about the antioxidant activities of buckwhear hull extract(BWHE). In the in vitro studies and an animal experiment to obtain information about the antioxidant activities of buckwheat hull extract(BWHE). Inthe in vitro studies, BWHE scavenged super oxide anion produced in the xanthine/xanthine oxdase(IC_<50>=11.4μg phenolic compound/ml), and strongly inhibited autoxidation of linoleic acid(IC_<50>=6.2μg pheonolic compound/ml). Low-density lipoprotein(LDL)oxdation infuced by Cu^<2+> ion was also protected by BWHE. In the aimal experiment, ddY mice were fed a standard diet supplemeted with 0.75% BWHE for 14d. In blood, liver and brain of the mice TBARS and fluorescent substance concentration were significantly decreased compared with those of non-treated mice. SOD like activity in serum also significantly rose by BWHE was shown to be effective for protecting biological systems against various oxidative stresses in vitro, and to have antioxidant activity in vivo.
公益社団法人日本薬学会の論文
2001-03-01